Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
AuthorsMcClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ,
JournalProc Natl Acad Sci U S A
PubMed ID15967985
'Although there are clear interactions between circadian rhythms and drug addiction, mechanisms for such interactions remain unknown. Here we establish a role for the Clock gene in regulating the brain''s reward circuit. Mice lacking a functional Clock gene display an increase in cocaine reward and in the excitability of dopamine ... More
Progesterone decreases tyrosine hydroxylase phosphorylation state and increases protein phosphatase 2A activity in the stalk-median eminence on proestrous afternoon.
AuthorsLiu B, Arbogast LA,
JournalJ Endocrinol
PubMed ID19945993
The progesterone (P(4)) rise on proestrous afternoon is associated with dephosphorylation of tyrosine hydroxylase (TH) and reduced TH activity in the stalk-median eminence (SME), which contributes to the proestrous prolactin surge in rats. In the present study, we investigated the time course for P(4) effect on TH activity and phosphorylation ... More