Assembly of the human origin recognition complex occurs through independent nuclear localization of its components.
AuthorsGhosh S, Vassilev AP, Zhang J, Zhao Y, DePamphilis ML,
JournalJ Biol Chem
PubMed ID21555516
Initiation of eukaryotic genome duplication begins when a six-subunit origin recognition complex (ORC) binds to DNA. However, the mechanism by which this occurs in vivo and the roles played by individual subunits appear to differ significantly among organisms. Previous studies identified a soluble human ORC(2-5) complex in the nucleus, an ... More