'TRAF2 is a RING finger protein that regulates the cellular response to stress and cytokines by controlling JNK, p38 and NF-kappaB signaling cascades. Here, we demonstrate that TRAF2 ubiquitination is required for TNFalpha-induced activation of JNK but not of p38 or NF-kappaB. Intact RING and zinc finger domains are required ... More
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
'The E2 ubiquitin-conjugating enzyme UBC13 plays pivotal roles in diverse biological processes. Recent studies have elucidated that UBC13, in concert with the E3 ubiquitin ligase RNF8, propagates the DNA damage signal via a ubiquitylation-dependent signaling pathway. However, mechanistically how UBC13 mediates its role in promoting checkpoint protein assembly and its ... More
Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
AuthorsWu X, Yamamoto M, Akira S, Sun SC,
JournalProc Natl Acad Sci U S A
PubMed ID19926860
The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene causes severe loss of multi lineages of immune cells, which ... More
TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.
AuthorsEa CK, Sun L, Inoue J, Chen ZJ,
JournalProc Natl Acad Sci U S A
PubMed ID15492226
TRAF6 (tumor necrosis factor receptor-associated factor 6) is a RING (really interesting new gene) domain ubiquitin (Ub) ligase that mediates the activation of protein kinases, such as transforming growth factor beta-activated kinase (TAK1) and IkappaB kinase (IKK), by catalyzing the formation of a unique polyubiquitin chain linked through Lys-63 of ... More