alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.
AuthorsBeg AA, Sommer JE, Martin JH, Scheiffele P,
JournalNeuron
PubMed ID17785183
'The assembly of neuronal networks during development requires tightly controlled cell-cell interactions. Multiple cell surface receptors that control axon guidance and synapse maturation have been identified. However, the signaling mechanisms downstream of these receptors have remained unclear. Receptor signals might be transmitted through dedicated signaling lines defined by specific effector ... More
The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.
AuthorsRichter M, Murai KK, Bourgin C, Pak DT, Pasquale EB,
JournalJ Neurosci
PubMed ID18094260
Eph receptors play critical roles in the establishment and remodeling of neuronal connections, but the signaling pathways involved are not fully understood. We have identified a novel interaction between the C terminus of the EphA4 receptor and the PDZ domain of the GTPase-activating protein spine-associated RapGAP (SPAR). In neuronal cells, ... More