EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.
AuthorsKoolpe M, Burgess R, Dail M, Pasquale EB,
JournalJ Biol Chem
PubMed ID15722342
The Eph receptor tyrosine kinases are overexpressed in many pathologic tissues and have therefore emerged as promising drug target candidates. However, there are few molecules available that can selectively bind to a single Eph receptor and not other members of this large receptor family. Here we report the identification by ... More