Early proliferation does not prevent the loss of oligodendrocyte progenitor cells during the chronic phase of secondary degeneration in a CNS white matter tract.
AuthorsPayne SC, Bartlett CA, Savigni DL, Harvey AR, Dunlop SA, Fitzgerald M,
Journal
PubMed ID23776532
'Partial injury to the central nervous system (CNS) is exacerbated by additional loss of neurons and glia via toxic events known as secondary degeneration. Using partial transection of the rat optic nerve (ON) as a model, we have previously shown that myelin decompaction persists during secondary degeneration. Failure to repair ... More
Axon growth across a lesion site along a preformed guidance pathway in the brain.
AuthorsJin Y, Ziemba KS, Smith GM,
JournalExp Neurol
PubMed ID18261727
Our previous studies showed that axonal outgrowth from dorsal root ganglia (DRG) transplants in the adult rat brain could be directed toward a specific target location using a preformed growth-supportive pathway. This pathway induced axon growth within the corpus callosum across the midline to the opposite hemisphere. In this study, ... More