Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. NO is synthesized from one of the guanidino nitrogens of L-arginine by the enzyme nitric oxide synthase (NOS). To date, several isoforms of NOS have been purified and cloned. These proteins represent a novel family ... More
Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats.
AuthorsSullivan JC, Pardieck JL, Hyndman KA, Pollock JS,
JournalAm J Physiol Regul Integr Comp Physiol
PubMed ID19889864
The goal of this study was to examine the status of the renal nitric oxide (NO) system by determining NO synthase (NOS) isoform activity and expression within the three regions of the kidney in 14-wk-old male and female spontaneously hypertensive rats (SHR). NOS activity, and NOS1 and NOS3 protein expressions ... More