Prostate-specific membrane antigen regulates angiogenesis by modulating integrin signal transduction.
AuthorsConway RE, Petrovic N, Li Z, Heston W, Wu D, Shapiro LH,
JournalMol Cell Biol
PubMed ID16809768
'The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis has not been investigated. Here we show that angiogenesis is severely impaired in PSMA-null animals and that this angiogenic defect occurs at the level of endothelial cell ... More