Dynamics of claudins expression in colitis and colitis-associated cancer in rat.
AuthorsArimura Y, Nagaishi K, Hosokawa M,
JournalMethods Mol Biol
PubMed ID21717373
'Claudins comprise a multigene family of 24 species and have been shown to constitute the backbone of tight junction strands in simple epithelial cells and to be directly involved in their barrier functions. Apical-most tight junction protein complexes (TJs) are implicated in inflammatory bowel disease (IBD) pathophysiology. Except for claudin-8, ... More
Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction.
AuthorsChang H, Zhang C, Cao Y,
JournalHistochem Cell Biol
PubMed ID22218735
Symplekin is multifunctional protein localized to both the tight junction and the nucleus with known roles in mRNA polyadenylation, proliferation, differentiation and tumorigenesis. Functions of symplekin at tight junctions have not been systematically investigated. In this study, increased expression of symplekin was observed during the formation of tight junctions in ... More
Gastroesophageal reflux activates the NF-?B pathway and impairs esophageal barrier function in mice.
AuthorsFang Y, Chen H, Hu Y, Djukic Z, Tevebaugh W, Shaheen NJ, Orlando RC, Hu J, Chen X,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID23639809
The barrier function of the esophageal epithelium is a major defense against gastroesophageal reflux disease. Previous studies have shown that reflux damage is reflected in a decrease in transepithelial electrical resistance associated with tight junction alterations in the esophageal epithelium. To develop novel therapies, it is critical to understand the ... More
Impact of intra- and interspecies variation of occludin on its function as coreceptor for authentic hepatitis C virus particles.
AuthorsCiesek S, Westhaus S, Wicht M, Wappler I, Henschen S, Sarrazin C, Hamdi N, Abdelaziz AI, Strassburg CP, Wedemeyer H, Manns MP, Pietschmann T, von Hahn T,
JournalJ Virol
PubMed ID21632765
Hepatitis C virus (HCV) is characterized by a narrow host range and high interindividual variability in the clinical course of infection. Both of these traits are thought to be largely due to genetic variation between species and between individual hosts. The tight junction component occludin (OCLN) is essential for HCV ... More
Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain.
AuthorsMullier A, Bouret SG, Prevot V, Dehouck B,
JournalJ Comp Neurol
PubMed ID20127760
The median eminence is one of the seven so-called circumventricular organs. It is located in the basal hypothalamus, ventral to the third ventricle and adjacent to the arcuate nucleus. This structure characteristically contains a rich capillary plexus and features a fenestrated endothelium, making it a direct target of blood-borne molecules. ... More