ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
AuthorsGao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW,
JournalJ Biol Chem
PubMed ID21885437
'Upon virus infection, the innate immune response provides the first line of protection and rapidly induces type I interferons (IFNa/ß), which mediate potent antiviral effects. To maintain homeostasis and prevent autoimmunity, IFN production is tightly regulated; however, the mechanisms of negative regulation are poorly understood. Herein, we demonstrate that the ... More