Calmodulin activation of polo-like kinase 1 is required during mitotic entry.
AuthorsDai G, Qian Y, Chen J, Meng FL, Pan FY, Shen WG, Zhang SZ, Xue B, Li CJ,
Journal
PubMed ID24032677
'Polo-like kinase 1 (Plk1) is a conserved key regulator of the G2/M transition, but its upstream spatiotemporal regulators remain unknown. With the help of immunofluorescence, co-immunoprecipitation, and glutathione S-transferase (GST) pull-down assay, we found that calmodulin (CaM) is one such regulatory molecule that associates with Plk1 from G2 to metaphase. ... More