Organophosphorous pesticide metabolite (DEDTP) induces changes in the activation status of human lymphocytes by modulating the interleukin 2 receptor signal transduction pathway.
AuthorsEsquivel-Sentíes MS, Barrera I, Ortega A, Vega L,
JournalToxicol Appl Pharmacol
PubMed ID20659491
Diethyldithiophosphate (DEDTP) is a metabolite formed by biotransformation of organophosphorous (OP) compounds that has a longer half-life than its parental compound. Here we evaluate the effects of DEDTP on human CD4+ T lymphocytes. In vitro exposure to DEDTP (1-50µM) decreased [(3)H]thymidine incorporation in resting cells and increased CD25 surface expression ... More