Calcium binding is essential for plastin 3 function in Smn-deficient motoneurons.
AuthorsLyon AN, Pineda RH, Hao le T, Kudryashova E, Kudryashov DS, Beattie CE,
Journal
PubMed ID24271012
'The actin-binding and bundling protein, plastin 3 (PLS3), was identified as a protective modifier of spinal muscular atrophy (SMA) in some patient populations and as a disease modifier in animal models of SMA. How it functions in this process, however, is not known. Because PLS3 is an actin-binding/bundling protein, we ... More
The c-myc DNA-unwinding element-binding protein modulates the assembly of DNA replication complexes in vitro.
AuthorsCasper JM, Kemp MG, Ghosh M, Randall GM, Vaillant A, Leffak M,
JournalJ Biol Chem
PubMed ID15653697
The presence of DNA-unwinding elements (DUEs) at eukaryotic replicators has raised the question of whether these elements contribute to origin activity by their intrinsic helical instability, as protein-binding sites, or both. We used the human c-myc DUE as bait in a yeast one-hybrid screen and identified a DUE-binding protein, designated ... More
DLC1 interaction with a-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.
AuthorsTripathi V, Popescu NC, Zimonjic DB,
JournalMol Cell Biol
PubMed ID22473989
The DLC1 (for deleted in liver cancer 1) tumor suppressor gene encodes a RhoGAP protein that inactivates Rho GTPases, which are implicated in regulation of the cytoskeleton and adherens junctions (AJs), a cell-cell adhesion protein complex associated with the actin cytoskeleton. Malignant transformation and tumor progression to metastasis are often ... More
The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin.
AuthorsBao X, Cai W, Deng H, Zhang W, Krencik R, Girton J, Johansen J, Johansen KM,
JournalJ Biol Chem
PubMed ID18819909
The JIL-1 histone H3S10 kinase in Drosophila localizes specifically to euchromatic interband regions of polytene chromosomes and is enriched 2-fold on the male X chromosome. JIL-1 can be divided into four main domains including an NH(2)-terminal domain, two separate kinase domains, and a COOH-terminal domain. Our results demonstrate that the ... More