The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells.
AuthorsChen M, Chen LM, Lin CY, Chai KX,
JournalBiochim Biophys Acta
PubMed ID18054338
Prostasin is expressed at the apical surface of normal epithelial cells and suppresses in vitro invasion of cancer cells. Prostasin re-expression in the PC-3 prostate carcinoma cells down-regulated the epidermal growth factor receptor (EGFR) protein expression and EGF-induced phosphorylation of the extracellular signal-regulated kinases (Erk1/2). We report here that prostasin ... More
Assaying tyrosine phosphorylation of insulin receptor and insulin receptor substrates.