Modification of alternative messenger RNA splicing of fibroblast growth factor receptors in human cardiac allografts during rejection.
AuthorsZhao XM, Frist WH, Yeoh TK, Miller GG,
JournalJ Clin Invest
PubMed ID7521891
'Accelerated coronary atherosclerosis in cardiac transplants (cardiac allograft vasculopathy, CAV) is characterized by coronary intimal hyperplasia. Acidic fibroblast growth factor (aFGF) is a potent mitogen for vascular smooth muscle cells and endothelial cells, and its expression is increased in cardiac allografts, suggesting it may play a role in the pathogenesis ... More
Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms.
AuthorsXu J, Nakahara M, Crabb JW, Shi E, Matuo Y, Fraser M, Kan M, Hou J, McKeehan WL,
JournalJ Biol Chem
PubMed ID1325449
Potentially 96 splice variants among four genes that code for the human heparin-binding fibroblast growth factor receptor family complicate study of structure, metabolism, and function of single isoforms in mammalian cells. As an alternative, we expressed structural subdomains and isoforms of the flg receptor gene in bacteria and baculoviral-infected insect ... More