Wnt6 expression in epidermis and epithelial tissues during Xenopus organogenesis.
AuthorsLavery DL, Davenport IR, Turnbull YD, Wheeler GN, Hoppler S,
JournalDev Dyn
PubMed ID18224714
'Here, we report the localization within embryonic tissues of xWnt6 protein; together with the temporal and spatial expression of Xenopus laevis Wnt6 mRNA. Wnt6 expression in Xenopus embryos is low until later stages of neurulation, when it is predominantly found in the surface ectoderm. Wnt6 expression increases during early organogenesis ... More
EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.
AuthorsNakamura PA, Hsieh CY, Cramer KS,
JournalDev Neurobiol
PubMed ID22021100
'Precision in auditory brainstem connectivity underlies sound localization. Cochlear activity is transmitted to the ventral cochlear nucleus (VCN) in the mammalian brainstem via the auditory nerve. VCN globular bushy cells project to the contralateral medial nucleus of the trapezoid body (MNTB), where specialized axons terminals, the calyces of Held, encapsulate ... More
Diverse roles of Eph/ephrin signaling in the mouse lens.
AuthorsCheng C, Gong X,
JournalPLoS One
PubMed ID22140528
Recent genetic studies show that the Eph/ephrin bidirectional signaling pathway is associated with both congenital and age-related cataracts in mice and humans. We have investigated the molecular mechanisms of cataractogenesis and the roles of ephrin-A5 and EphA2 in the lens. Ephrin-A5 knockout ?/? mice often display anterior polar cataracts while ... More