TRAF6 Stimulates the Tumor-Promoting Effects of TGFß Type I Receptor Through Polyubiquitination and Activation of Presenilin 1.
AuthorsGudey SK, Sundar R, Mu Y, Wallenius A, Zang G, Bergh A, Heldin CH, Landström M,
Journal
PubMed ID24399296
'Transforming growth factor-ß (TGFß) can be both a tumor promoter and suppressor, although the mechanisms behind the protumorigenic switch remain to be fully elucidated. The TGFß type I receptor (TßRI) is proteolytically cleaved in the ectodomain region. Cleavage requires the combined activities of tumor necrosis factor (TNF) receptor-associated factor 6 ... More