HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8.
AuthorsChen H, Chung S, Sukumar S,
JournalMol Cell Biol
PubMed ID14701762
'HOXA5 is a transcriptional factor whose expression is lost in more than 60% of breast carcinomas. Our previous work demonstrated that the overexpression of HOXA5 in MCF7 cells resulted in cell death through a p53-dependent apoptotic pathway. To determine whether p53-independent apoptotic pathways are involved in HOXA5-induced cell death, we ... More
Identification of transcriptional targets of HOXA5.
AuthorsChen H, Rubin E, Zhang H, Chung S, Jie CC, Garrett E, Biswal S, Sukumar S
JournalJ Biol Chem
PubMed ID15757903
'The homeobox gene HOXA5 encodes a transcription factor that has been shown to play important roles in embryogenesis, hematopoiesis, and tumorigenesis. In order to decipher downstream signaling pathways of HOXA5, we utilized oligonucleotide microarray analysis to identify genes that are differentially expressed in HOXA5-induced cells compared with uninduced cells. Comparative ... More