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Invitrogen
PITX3 Polyclonal Antibody
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FIGURE: 1 / 10
PITX3 Antibody (38-2850) in IHC
Immunofluorescent staining of PiTX3 expression (red) co-localized with tyrosine hydroxylase (green) in dopaminergic neurons of substantia nigra pars compacta (SNc) in mouse brain using Rb anti-PiTX3 (Product # 38-2850). Image courtesy of Paul J. Shughrue, PhD.
Product Details
38-2850
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from the N-terminal region of the mouse PiTX3 protein.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: aphakia; Homeobox protein PITX3; MGC12766; Paired-like homeodomain transcription factor 3; Pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3)
Gene Aliases: ak; Pitx3; Ptx3
UniProt ID: (Mouse) O35160
Entrez Gene ID: (Mouse) 18742
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
lens development in camera-type eye
lens morphogenesis in camera-type eye
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
locomotory behavior
regulation of gene expression
midbrain development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron development
lens fiber cell differentiation
dopaminergic neuron differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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