Wnt6 signaling regulates heart muscle development during organogenesis.
AuthorsLavery DL, Martin J, Turnbull YD, Hoppler S,
JournalDev Biol
PubMed ID18804460
'Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic mesoderm; however, the identity of the inhibiting Wnt signal itself ... More