AuthorsWang Y, Huang JW, Castella M, Huntsman DG, Taniguchi T,
Journal
PubMed ID24762395
'The tumor suppressor p53 and miRNAs are linked through a complex network. Several miRNAs modulate p53 expression, while p53 regulates the transcription and/or biogenesis of several other miRNAs. Here, we report the development of a cell-based assay used with a library of human miRNA mimics in a high-throughput screen for ... More
Regulation of REG? cellular distribution and function by SUMO modification.
AuthorsWu Y, Wang L, Zhou P, Wang G, Zeng Y, Wang Y, Liu J, Zhang B, Liu S, Luo H, Li X,
JournalCell Res
PubMed ID21445096
Discovery of emerging REG?-regulated proteins has accentuated the REG?-proteasome as an important pathway in multiple biological processes, including cell growth, cell cycle regulation, and apoptosis. However, little is known about the regulation of the REG?-proteasome pathway. Here we demonstrate that REG? can be SUMOylated in vitro and in vivo by ... More
Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.
AuthorsYing H, Furuya F, Zhao L, Araki O, West BL, Hanover JA, Willingham MC, Cheng SY,
JournalJ Clin Invest
PubMed ID17039256
Overexpression of pituitary tumor-transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma (TRbeta(PV/PV) mice). Here we examined the molecular mechanisms underlying elevated PTTG1 levels and the contribution of increased PTTG1 to thyroid carcinogenesis. We ... More