BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.
AuthorsSehgal R, Sheibani N, Rhodes SJ, Belecky Adams TL,
JournalDev Biol
PubMed ID19505455
'Pax2 is essential for development of the neural tube, urogenital system, optic vesicle, optic cup and optic tract. In the eye, Pax2 deficiency is associated with coloboma, a loss of astrocytes in the optic nerve and retina, and abnormal axonal pathfinding of the ganglion cell axons at the optic chiasm. ... More
Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
AuthorsKrause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Löwik CW, ten Dijke P
JournalJ Biol Chem
PubMed ID20952383
Sclerostin is expressed by osteocytes and has catabolic effects on bone. It has been shown to antagonize bone morphogenetic protein (BMP) and/or Wnt activity, although at present the underlying mechanisms are unclear. Consistent with previous findings, Sclerostin opposed direct Wnt3a-induced but not direct BMP7-induced responses when both ligand and antagonist ... More