Overexpression of active Aurora-C kinase results in cell transformation and tumour formation.
AuthorsKhan J, Ezan F, Crémet JY, Fautrel A, Gilot D, Lambert M, Benaud C, Troadec MB, Prigent C,
JournalPLoS One
PubMed ID22046298
Aurora kinases belong to a conserved family of serine/threonine kinases key regulators of cell cycle progression. Aurora-A and Aurora-B are expressed in somatic cells and involved mainly in mitosis while Aurora-C is expressed during spermatogenesis and oogenesis and is involved in meiosis. Aurora-C is hardly detectable in normal somatic cells. ... More
Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment.
AuthorsWiseman SM, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, Bugis S, Filipenko D, Huntsman D, Gilks B,
JournalAnn Surg Oncol
PubMed ID17115102
Anaplastic thyroid cancer is an endocrine malignancy. Its rare and rapidly lethal disease course has made it challenging to study. Little is known regarding the expression by anaplastic tumors of molecular targets for new human anticancer agents that have been studied in the preclinical or clinical setting. The objective of ... More
Aurora-B regulates RNA methyltransferase NSUN2.
AuthorsSakita-Suto S, Kanda A, Suzuki F, Sato S, Takata T, Tatsuka M,
JournalMol Biol Cell
PubMed ID17215513
Disassembly of the nucleolus during mitosis is driven by phosphorylation of nucleolar proteins. RNA processing stops until completion of nucleolar reformation in G(1) phase. Here, we describe the RNA methyltransferase NSUN2, a novel substrate of Aurora-B that contains an NOL1/NOP2/sun domain. NSUN2 was concentrated in the nucleolus during interphase and ... More