Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures.
AuthorsHumtsoe JO, Liu M, Malik AB, Wary KK,
JournalMol Cell Biol
PubMed ID20123964
'Endothelial cell (EC) migration, cell-cell adhesion, and the formation of branching point structures are considered hallmarks of angiogenesis; however, the underlying mechanisms of these processes are not well understood. Lipid phosphate phosphatase 3 (LPP3) is a recently described p120-catenin-associated integrin ligand localized in adherens junctions (AJs) of ECs. Here, we ... More
Lipid phosphate phosphatase-3 regulates tumor growth via ß-catenin and CYCLIN-D1 signaling.
AuthorsChatterjee I, Humtsoe JO, Kohler EE, Sorio C, Wary KK,
JournalMol Cancer
PubMed ID21569306
'The acquisition of proliferative and invasive phenotypes is considered a hallmark of neoplastic transformation; however, the underlying mechanisms are less well known. Lipid phosphate phosphatase-3 (LPP3) not only catalyzes the dephosphorylation of the bioactive lipid sphingosine-1-phosphate (S1P) to generate sphingosine but also may regulate embryonic development and angiogenesis via the ... More