Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav.
AuthorsChen CH, Martin VA, Gorenstein NM, Geahlen RL, Post CB,
JournalMol Cell Biol
PubMed ID21606197
'Activated Syk, an essential tyrosine kinase in B cell signaling, interacts with Vav guanine nucleotide exchange factors and regulates Vav activity through tyrosine phosphorylation. The Vav SH2 domain binds Syk linker B by an unusual recognition of two closely spaced Syk tyrosines: Y342 and Y346. The binding affinity is highest ... More