The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.
AuthorsVazquez-Martin A, Oliveras-Ferraros C, Menendez JA,
JournalCell Cycle
PubMed ID19556893
'The metabolic rheostat AMP-activated protein kinase (AMPK) is unexpectedly required for proper cell division and faithful chromosomal segregation during mitosis. Although it is conceptually attractive to assume that AMPK-interpreted microenvironmental bioenergetics may strictly engage cell''s energy status, cell grow, and cell division to avoid that energy stresses trigger cell death, ... More