Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
AuthorsCook BD, Liu S, Evans T,
JournalBlood
PubMed ID21515822
Bone morphogenetic protein (BMP) signaling regulates embryonic hematopoiesis via receptor-mediated activation of downstream SMAD proteins, including SMAD1. In previous work, we showed that Smad1 expression is sufficient to enhance commitment of mesoderm to hemangioblast fate. We also found indirect evidence to support a subsequent repressive function for Smad1 in hematopoiesis. ... More