KU812 cells provide a novel in vitro model of the human IL-33/ST2L axis: functional responses and identification of signaling pathways.
AuthorsTare N, Li H, Morschauser A, Cote-Sierra J, Ju G, Renzetti L, Lin TA,
JournalExp Cell Res
PubMed ID20406635
Activation of interleukin-1 family receptor ST2L by its ligand interleukin-33 (IL-33) is an important component in inflammatory responses. Peripheral blood basophils, recognized as major effector cells in allergic inflammation that play a role in both innate and adaptive immunity, are activated by IL-33 through ST2L. However, studies are challenging due ... More