Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.
AuthorsChangsirivathanathamrong D, Wang Y, Rajbhandari D, Maghzal GJ, Mak WM, Woolfe C, Duflou J, Gebski V, dos Remedios CG, Celermajer DS, Stocker R,
JournalCrit Care Med
PubMed ID21765346
To determine whether tryptophan metabolism to kynurenine contributes to the direct regulation of vascular tone in human septic shock. Indoleamine 2,3-dioxygenase 1 is an inducible enzyme that converts tryptophan to kynurenine and shares functional similarities with inducible nitric oxide synthase. Recently, kynurenine has been identified as an endothelium-derived relaxing factor ... More