Localization of phosphorylated SMAD proteins in granulosa cells, oocytes and oviduct of female mice.
AuthorsTian X, Halfhill AN, Diaz FJ,
JournalGene Expr Patterns
PubMed ID20176141
'SMAD signaling is essential for follicular development. The distribution of activated (phosphorylated) SMADs during folliculogenesis has not been described in detail. The present results indicate that oocytes from preantral and antral follicles contain the mRNA for the receptor regulated Smads (-1, -2, -3, -5 and -9), Smad4 (co-SMAD), and Smad6 ... More
Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.
AuthorsSimon DP, Vadakkadath Meethal S, Wilson AC, Gallego MJ, Weinecke SL, Bruce E, Lyons PF, Haasl RJ, Bowen RL, Atwood CS,
JournalNeoplasia
PubMed ID19308291
Mutational changes coupled with endocrine, paracrine, and/or autocrine signals regulate cell division during carcinogenesis. The hormone signals remain undefined, although the absolute requirement in vitro for fetal serum indicates the necessity for a fetal serum factor(s) in cell proliferation. Using prostatic cancer cell (PCC) lines as a model of cancer ... More
Embryonic overexpression of Galgt2 inhibits skeletal muscle growth via activation of myostatin signaling.
AuthorsChandraskeharan K, Martin PT,
JournalMuscle Nerve
PubMed ID19086062
Many proteins that affect skeletal muscle growth are secreted glycoproteins, yet the nature of how glycosylation regulates the expression and growth-promoting properties of such factors is not well understood. One type of glycosylation that affects muscle growth is that controlled by the CT GalNAc transferase (Galgt2), the enzyme responsible for ... More