Dual effects of Sprouty1 on TCR signaling depending on the differentiation state of the T cell.
AuthorsChoi H, Cho SY, Schwartz RH, Choi K,
JournalJ Immunol
PubMed ID16670312
'Sprouty (Spry) is known to be a negative feedback inhibitor of growth factor receptor signaling through inhibition of the Ras/MAPK pathway. Several groups, however, have reported a positive role for Spry involving sequestration of the inhibitory protein c-Cbl. Thus, Spry may have various functions in the regulation of receptor-mediated signaling ... More
Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program.
AuthorsLagha M, Kormish JD, Rocancourt D, Manceau M, Epstein JA, Zaret KS, Relaix F, Buckingham ME,
JournalGenes Dev
PubMed ID18593883
Pax3/7-dependent stem cells play an essential role in skeletal muscle development. We now show that Fgfr4 lies genetically downstream from Pax3 and is a direct target. In chromatin immunoprecipitation (ChIP)-on-chip experiments, Pax3 binds to a sequence 3' of the Fgfr4 gene that directs Pax3-dependent expression at sites of myogenesis in ... More