Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy.
AuthorsBarrett DM, Singh N, Liu X, Jiang S, June CH, Grupp SA, Zhao Y,
Journal
PubMed ID24439255
'Cytotoxic T lymphocytes modified with chimeric antigen receptors (CARs) for adoptive immunotherapy of hematologic malignancies are effective in pre-clinical models, and this efficacy has translated to success in several clinical trials. Many early trials were disappointing in large part because of the lack of proliferation and subsequent persistence of transferred ... More
Simplified process for the production of anti-CD19-CAR-engineered T cells.
AuthorsTumaini B, Lee DW, Lin T, Castiello L, Stroncek DF, Mackall C, Wayne A, Sabatino M,
Journal
PubMed ID23992830
Adoptive immunotherapy with the use of chimeric antigen receptor (CAR)-engineered T cells specific for CD19 has shown promising results for the treatment of B-cell lymphomas and leukemia. This therapy involves the transduction of autologous T cells with a viral vector and the subsequent cell expansion. We describe a new, simplified ... More