Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs.
AuthorsMan Z, Kondo Y, Koga H, Umino H, Nakayama K, Shin HW
JournalJ Biol Chem
PubMed ID21239483
Arfaptins (arfaptin-1 and arfaptin-2/POR1) were originally identified as binding partners of the Arf small GTPases. Both proteins contain a BAR (Bin/Amphiphysin/Rvs) domain, which participates in membrane deformation. Here we show that arfaptins associate with trans-Golgi membranes. Unexpectedly, Arl1 (Arf-like 1), but not Arfs, determines the trans-Golgi association of arfaptins. We ... More