Induction of antitumor immunity by dendritic cells loaded with membrane-translocating mucin 1 Peptide antigen.
AuthorsKobukai S, Kremers GJ, Cobb JG, Baheza R, Xie J, Kuley A, Zhu M, Pham W,
JournalTransl Oncol
PubMed ID21286372
'To investigate the role of enhanced antigen presentation in dendritic cell (DC)-based immunotherapy. Here, we describe the development of a cell-penetrating mucin 1 (MUC1) antigen and its immunotherapeutic potential against tumors. After animal groups received two immunizations of MUC1-MPA(11)P-pulsed DCs, we observed a marked tumor regression compared with the mice ... More
p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis.
AuthorsJolly PS, Berkowitz P, Bektas M, Lee HE, Chua M, Diaz LA, Rubenstein DS,
JournalJ Biol Chem
PubMed ID20093368
Pemphigus vulgaris (PV) is an autoimmune blistering disease in which antibodies against the desmosomal cadherin, DSG3 (desmoglein-3), cause acantholysis. It has become increasingly clear that loss of cell-cell adhesion in PV is a complex and active process involving multiple signaling events such as activation of p38MAPK. It has also been ... More