Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury.
AuthorsHua F, Ma J, Ha T, Kelley J, Williams DL, Kao RL, Kalbfleisch JH, Browder IW, Li C
JournalJ Neuroimmunol
PubMed ID18585792
'The brain''s resistance to ischemic injury can be transiently augmented by prior exposure to a sub-lethal stress stimulus, i.e. preconditioning. It has been reported that Toll-like receptors (TLRs) are involved in the preconditioning-induced protective effect against ischemic brain injury. In this study, we investigated the effect of preconditioning with a ... More
Anti-inflammatory and antioxidant effects of SERPINA3K in the retina.
AuthorsZhang B, Hu Y, Ma JX,
JournalInvest Ophthalmol Vis Sci
PubMed ID19324842
Previous studies by the authors have shown that retinal levels of SERPINA3K, a serine proteinase inhibitor, are decreased in an animal model with diabetic retinopathy (DR). The purpose of this study was to investigate the function of SERPINA3K and its role in DR. For the oxygen-induced retinopathy (OIR) model, newborn ... More
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
AuthorsWang Y, Rattner A, Zhou Y, Williams J, Smallwood PM, Nathans J,
JournalCell
PubMed ID23217714
Norrin/Frizzled4 (Fz4) signaling activates the canonical Wnt pathway to control retinal vascular development. Using genetically engineered mice, we show that precocious Norrin production leads to premature retinal vascular invasion and delayed Norrin production leads to characteristic defects in intraretinal vascular architecture. In genetic mosaics, wild-type endothelial cells (ECs) instruct neighboring ... More