Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice.
AuthorsLipina TV, Wang M, Liu F, Roder JC,
JournalNeuropharmacology
PubMed ID21376063
'Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders. Two distinct mutations in the second exon of the DISC1 gene (Q31L and L100P) lead to either depression- or schizophrenia-like behavior in mice. Both phosphodiesterase-4B (PDE4B) and glycogen synthase kinase-3 (GSK-3) have common binding sites on N-terminal region ... More
DISC1 regulates primary cilia that display specific dopamine receptors.
AuthorsMarley A, von Zastrow M,
JournalPLoS One
PubMed ID20531939
'Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identified a role of DISC1 in the cell biology of primary cilia that display disease-relevant dopamine receptors. ... More
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.
AuthorsLipina TV, Kaidanovich-Beilin O, Patel S, Wang M, Clapcote SJ, Liu F, Woodgett JR, Roder JC,
JournalSynapse
PubMed ID20687111
'Recent studies have identified disrupted-in-schizophrenia-1 (DISC1) as a strong genetic risk factor associated with schizophrenia. Previously, we have reported that a mutation in the second exon of the DISC1 gene [leucine to proline at amino acid position 100, L100P] leads to the development of schizophrenia-related behaviors in mice. Glycogen synthase ... More
The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans.
The von Economo neurons (VENs) are large bipolar neurons located in frontoinsular (FI) and anterior cingulate cortex in great apes and humans, but not other primates. We performed stereological counts of the VENs in FI and LA (limbic anterior, a component of anterior cingulate cortex) in great apes and in ... More