DISC1 regulates primary cilia that display specific dopamine receptors.
AuthorsMarley A, von Zastrow M,
JournalPLoS One
PubMed ID20531939
'Mutations in the DISC1 gene are strongly associated with major psychiatric syndromes such as schizophrenia. DISC1 encodes a cytoplasmic protein with many potential interaction partners, but its cellular functions remain poorly understood. We identified a role of DISC1 in the cell biology of primary cilia that display disease-relevant dopamine receptors. ... More
Disc1 regulates granule cell migration in the developing hippocampus.
AuthorsMeyer KD, Morris JA,
JournalHum Mol Genet
PubMed ID19502360
'Schizophrenia is a severely debilitating psychiatric disease that is hypothesized to have its roots in neurodevelopment. Although the precise neuropathology underlying schizophrenia has remained elusive, there are consistent reports of abnormalities in several brain areas. Chief among these is the hippocampus, an area which has displayed both structural and functional ... More