Targeting of junctional adhesion molecule-C inhibits experimental choroidal neovascularization.
AuthorsHou X, Hu D, Wang YS, Tang ZS, Zhang F, Chavakis T, Li Y, Li X,
JournalInvest Ophthalmol Vis Sci
PubMed ID22323465
'To identify the expression of junctional adhesion molecule-C (JAM-C) in choroidal neovascularization (CNV) and evaluate the effect of JAM-C targeting on CNV formation and on cellular functions relevant to CNV in vitro, such as macrophage transmigration, human retinal pigment epithelial (hRPE) cell migration, and monolayer RPE permeability. JAM-C expression in ... More
Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies.
AuthorsBetanzos A, Schnoor M, Severson EA, Liang TW, Parkos CA
JournalBiol Cell
PubMed ID19143587
JAM-C (junctional adhesion molecule C) has been implicated in the regulation of leukocyte migration, cell polarity, spermatogenesis, angiogenesis and nerve conduction. JAM-C has been also reported to concentrate at TJs (tight junctions) and desmosomes, although detailed localization studies remain incomplete. ... More
Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility.
AuthorsMok KW, Mruk DD, Lee WM, Cheng CY
JournalInt J Androl
PubMed ID21696392
The blood-testis barrier (BTB) is a unique ultrastructure in the testis, which creates a specialized microenvironment in the seminiferous epithelium known as the apical (or adluminal) compartment for post-meiotic germ-cell development and for maintenance of an immunological barrier. In this study, we have demonstrated unequivocally that a functional and intact ... More