Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).
AuthorsSolter D, Knowles BB,
JournalProc Natl Acad Sci U S A
PubMed ID281705
A monoclonal antibody derived by fusion of mouse myeloma cells with spleen cells from a mouse immunized with F9 teratocarcinoma cells is described. This antibody, which reacts with embryonal carcinoma cells of mouse and human origin and with some preimplantation stage mouse embryos, defines an embryonic stage-specific antigen. This stage-specific ... More
Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours.
AuthorsAndrews PW, Casper J, Damjanov I, Duggan-Keen M, Giwercman A, Hata J, von Keitz A, Looijenga LH, Millán JL, Oosterhuis JW, Pera M, Sawada M, Schmoll HJ, Skakkebaek NE, van Putten W, Stern P,
JournalInt J Cancer
PubMed ID8647654
The pattern of cell surface antigen expression of a set of cell lines derived from human germ cell tumours and corresponding to various cell phenotypes found within these tumours was studied using immunofluorescence. Twenty-two different antibodies were used. Many of these antibodies have been noted to recognise epitopes that are ... More
Preimplantation human embryos and embryonic stem cells show comparable expression of stage-specific embryonic antigens.
Cell-surface antigens provide invaluable tools for the identification of cells and for the analysis of cell differentiation. In particular, stage-specific embryonic antigens that are developmentally regulated during early embryogenesis are widely used as markers to monitor the differentiation of both mouse and human embryonic stem (ES) cells and their malignant ... More