PACSIN proteins bind tubulin and promote microtubule assembly.
AuthorsGrimm-Günter EM, Milbrandt M, Merkl B, Paulsson M, Plomann M,
JournalExp Cell Res
PubMed ID18456257
'PACSINs are intracellular adapter proteins involved in vesicle transport, membrane dynamics and actin reorganisation. In this study, we report a novel role for PACSIN proteins as components of the centrosome involved in microtubule dynamics. Glutathione S-transferase (GST)-tagged PACSIN proteins interacted with protein complexes containing alpha- and gamma-tubulin in brain homogenate. ... More