Regulation of N-Myc downstream regulated gene 2 by bile acids.
AuthorsLanghi C, Pedraz-Cuesta E, Donate Y, Marrero PF, Haro D, Rodríguez JC,
JournalBiochem Biophys Res Commun
PubMed ID23541942
Here we report that bile acid chenodeoxycholic acid (CDCA) and synthetic farnesoid X receptor (FXR) agonist GW4064 robustly induced tumor suppressor N-Myc downstream regulated gene 2 (NDRG2) expression in human hepatoma cells and primary hepatocytes. Knockdown of FXR abolished the induction by CDCA, whereas overexpression of a constitutively active form ... More