Podocytes require the engagement of cell surface heparan sulfate proteoglycans for adhesion to extracellular matrices.
AuthorsChen S, Wassenhove-McCarthy D, Yamaguchi Y, Holzman L, van Kuppevelt TH, Orr AW, Funk S, Woods A, McCarthy K,
JournalKidney Int
PubMed ID20463653
Podocytes adhere to the glomerular basement membrane by cell surface receptors. Since in other cells these adhesions are enhanced by cell surface proteoglycans, we examined the contribution of these molecules and their glycosaminoglycan side chains to podocyte adhesion by developing immortalized podocyte cell lines with (control) or without (mutant) heparan ... More