Matrigel improves functional properties of primary human salivary gland cells.
AuthorsMaria OM, Zeitouni A, Gologan O, Tran SD
JournalTissue Eng Part A
PubMed ID21189069
'Currently, there is no effective treatment available to patients with irreversible loss of functional salivary acini caused by Sjogren''s syndrome or after radiotherapy for head and neck cancer. A tissue-engineered artificial salivary gland would help these patients. The graft cells for this device must establish tight junctions in addition to ... More
Distribution of tight junction proteins in adult human salivary glands.
AuthorsMaria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD
JournalJ Histochem Cytochem
PubMed ID18765838
'Tight junctions (TJs) are an essential structure of fluid-secreting cells, such as those in salivary glands. Three major families of integral membrane proteins have been identified as components of the TJ: claudins, occludin, and junctional adhesion molecules (JAMs), plus the cytosolic protein zonula occludens (ZO). We have been working to ... More