Pannexins are new molecular candidates for assembling gap junctions in the cochlea.
AuthorsTang W, Ahmad S, Shestopalov VI, Lin X,
JournalNeuroreport
PubMed ID18695503
Genetic studies have linked many nonsyndromic deafness patients to mutations in genes coding for gap junction proteins. To better understand molecular identities of gap junctions in the cochlea, we investigated the expression of pannexins (Panxs). Western blot and reverse transcription-PCR detected the expression of Panx1 and Panx2. Immunolabeling localized Panx1 ... More