Hyposmotic stress causes ATP release and stimulates Na,K-ATPase activity in porcine lens.
AuthorsShahidullah M, Mandal A, Beimgraben C, Delamere NA,
JournalJ Cell Physiol
PubMed ID21618533
'Purinergic receptors in lens epithelium suggest lens function can be altered by chemical signals from aqueous humor or the lens itself. Here we show release of ATP by intact porcine lenses exposed to hyposmotic solution (200 mOsm). 18a-glycyrrhetinic acid (AGA) added together with probenecid eliminated the ATP increase. N-ethylmaleimide (200 ... More