A novel Fbxo25 acts as an E3 ligase for destructing cardiac specific transcription factors.
AuthorsJang JW, Lee WY, Lee JH, Moon SH, Kim CH, Chung HM,
JournalBiochem Biophys Res Commun
PubMed ID21596019
Alterations in ubiquitin-proteasome system (UPS) have been implicated in the etiology of human cardiovascular diseases. Skp1/Cul1/F-box (SCF) ubiquitin E3 ligase complex plays a pivotal role in ubiquitination of cardiac proteins. However, a specific ubiquitin E3 ligase responsible for the destruction of cardiac transcription factors such as Nkx2-5, Isl1, Mef2C, and ... More