An aberrant cerebellar development in mice lacking matrix metalloproteinase-3.
AuthorsVan Hove I, Verslegers M, Buyens T, Delorme N, Lemmens K, Stroobants S, Gantois I, D'Hooge R, Moons L,
JournalMol Neurobiol
PubMed ID22108898
'Cell-cell and cell-matrix interactions are necessary for neuronal patterning and brain wiring during development. Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of remodelling the pericellular environment and regulating signaling pathways through cleavage of a large degradome. MMPs have been suggested to affect cerebellar development, but the specific role of different ... More