Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.
Authors Colige Alain; Vandenberghe Isabel; Thiry Marc; Lambert Charles A; Van Beeumen Jozef; Li Shi-Wu; Prockop Darwin J; Lapiere Charles M; Nusgens Betty V;
JournalJ Biol Chem
PubMed ID11741898
The processing of amino- and carboxyl-propeptides of fibrillar collagens is required to generate collagen monomers that correctly assemble into fibrils. Mutations in the ADAMTS2 gene, the aminopropeptidase of procollagen I and II, result in the accumulation of non-fully processed type I procollagen, causing human Ehlers-Danlos syndrome type VIIC and animal ... More