PCDNA3.1(+) KIT

Name: PCDNA3.1(+) KIT
SKU: 430018

货号 430018

价格（CNY)

PCDNA3.1(+) KIT

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引用和文献 (25)

引用和文献

Abstract

An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement.

Authors:Vollenweider P, Clodi M, Martin SS, Imamura T, Kavanaugh WM, Olefsky JM

Journal:Mol Cell Biol

PubMed ID:9891043

'Tyrosine kinase receptors lead to rapid activation of phosphatidylinositol 3-kinase (PI3 kinase) and the subsequent formation of phosphatidylinositides (PtdIns) 3,4-P2 and PtdIns 3,4, 5-P3, which are thought to be involved in signaling for glucose transporter GLUT4 translocation, cytoskeletal rearrangement, and DNA synthesis. However, the specific role of each of these ... More

Targeting of EBNA1 for rapid intracellular degradation overrides the inhibitory effects of the Gly-Ala repeat domain and restores CD8+ T cell recognition.

Authors: Tellam J; Sherritt M; Thomson S; Tellam R; Moss D J; Burrows S R; Wiertz E; Khanna R;

Journal:J Biol Chem

PubMed ID:11435434

'Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) includes a unique glycine-alanine repeat domain that inhibits the endogenous presentation of cytotoxic T lymphocyte (CTL) epitopes through the class I pathway by blocking proteasome-dependent degradation of this antigen. This immune evasion mechanism has been implicated in the pathogenesis of EBV-associated diseases. Here, ... More

The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

Authors:Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ,

Journal:Neuron

PubMed ID:11988176

'Many central neurons possess large acid-activated currents, yet their molecular identity is unknown. We found that eliminating the acid sensing ion channel (ASIC) abolished H(+)-gated currents in hippocampal neurons. Neuronal H(+)-gated currents and transient acidification are proposed to play a role in synaptic transmission. Investigating this possibility, we found ASIC ... More

Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer.

Authors:Pavel Iserovich, Dong Wang, Li Ma, Hong Yang, Felipe A. Zuniga, Juan M. Pascual, Kunyan Kuang, Darryl C. De Vivo, Jorge Fischbarg

Journal:J Biol Chem

PubMed ID:12032147

'We studied glucose and water passage across wild type (WT) glucose transporter Glut1 and its T310I pathogenic mutant, expressing them in Xenopus laevis oocytes. We found that the T310I mutation produced a 8-fold decrease in glucose transport (zero-trans influx, 13 +/- 2% compared with WT), accompanied by a 2.8-fold increase ... More

Translocation-arrested apolipoprotein B evades proteasome degradation via a sterol-sensitive block in ubiquitin conjugation.

Authors:Du EZ, Fleming JF, Wang SL, Spitsen GM, Davis RA

Journal:J Biol Chem

PubMed ID:9880570

'In this study, we explored how sterol metabolism altered by the expression of cholesterol-7alpha-hydroxylase NADPH:oxygen oxidoreductase (7alpha-hydroxylase) affects the ubiquitin-dependent proteasome degradation of translocation-arrested apoB53 in Chinese hamster ovary cells. Stable expression of two different plasmids that encode either rat or human 7alpha-hydroxylase inhibited the ubiquitin conjugation of apoB and ... More

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