ADP-ribosylation factor 1 and its activation of phospholipase D are important for the assembly of very low density lipoproteins.
AuthorsAsp L, Claesson C, Boren J, Olofsson SO,
JournalJ Biol Chem
PubMed ID10843997
The role of ADP-ribosylation factor 1 (ARF-1) in the assembly of very low density lipoproteins (VLDL) was investigated by expressing dominant-negative mutants in McA-RH7777 cells. Transient expression of ARF-1(T31N), a GDP-restrictive mutant, significantly inhibited apolipoprotein B-100 (apoB-100) VLDL production without influencing the biosynthesis of apoB-100 low density lipoproteins or total ... More